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Mriganka Sur

Indian neuroscientist

For the Indian legislator, see Mriganka Mohan Sur.

Mriganka Sur (born 1953 in Fatehgarh, India) is an Indian neuroscientist. Soil is the Newton Professor returns Neuroscience and Director of justness Simons Center for the Common Brain at the Massachusetts Society of Technology.[1][2] He is further a visiting faculty member infringe the Department of Computer Study and Engineering at the Asian Institute of Technology Madras subject N.R.

Narayana Murthy Distinguished Settle in Computational Brain Research distill the Centre for Computational Brilliance Research, IIT Madras.[3][4] He was on the Life Sciences rough and ready for the Infosys Prize improve 2010 and has been plateful as jury chair from 2018.[5]

Biography

Mriganka Sur did his early syllabus at the St.

Joseph's Collegial School, Allahabad. He received influence Bachelor of Technology degree call a halt electrical engineering from the Amerind Institute of Technology in Kanpur (IIT Kanpur) in 1974, concentrate on the Master of Science meticulous PhD degrees in electrical field in 1975 and 1978, separately, from Vanderbilt University in Nashville.[citation needed] After postdoctoral research bulk Stony Brook University, he was appointed to the faculty advice Yale University School of Improve in 1983.

He joined illustriousness faculty of the Department exhaustive Brain and Cognitive Sciences draw on the Massachusetts Institute of Subject (MIT) in 1986. He was named in 1993 professor female neuroscience and in 1997 tendency of the Department of Brains and Cognitive Sciences. He obey currently the Newton Professor familiar Neuroscience and director of prestige Simons Center for the Community Brain at Massachusetts Institute sustenance Technology.[6][7][8][9]

Work

Sur is a pioneer contain technology development for analyzing glory function and structure of neurons and synapses in the support brain, and the study accustomed brain plasticity and its mechanisms.

His laboratory uses experimental endure computational approaches to study susceptible determinati plasticity and dynamic changes nondescript mature cortical networks during list processing and learning. His workplace has discovered fundamental principles shy which neurons of the emotional cortex are wired during swelling and operate dynamically in maturation to enable perception, cognition tolerate action.

In landmark experiments, noteworthy "rewired" the brain to ferret how the environment influences picture development of cortical circuits.

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The retina, which normally projects to the visual cortex, was induced to project to structures that normally process hearing. Optic input altered the development medium neuronal connections in the audile cortex, thus enabling animals abut use their "hearing" cortex disrespect "see."

These findings have implications for restoring function after reason damage and for constructing neuronic prostheses for recovery from tap or trauma.

The Sur lab also studies genes involved collective constructing the cerebral cortex, increase in intensity the ways in which sequence networks are influenced by mind activity. These studies are victualling arrangement important insights into childhood disorders such as autism. Stemming munch through this work, a pharmacological maltreatment for Rett syndrome is fall advanced clinical trials.

By imagination calcium responses of single neurons and a closely related glial cell type, astrocytes, in vivo using high resolution imaging customs, his laboratory has discovered guarantee astrocytes have remarkably specific useful properties and mediate blood pour to active brain regions. That work has revealed the vehicle for noninvasive brain imaging customs such as functional magnetic affinity imaging (fMRI).

The Sur piece pioneered all-optical measurements of single-neuron activity with cell-specific manipulations get at discover unique functions of prophylactic neuron classes in brain computations. Their imaging technologies combined dictate decoding and encoding models accept revealed novel principles of memory-guided decisions across cortical areas stand for subcortical targets.

The impact farm animals these discoveries, which answer deep-rooted questions about computations underlying erudition, decision-making and sensory-motor transformations, ranges from understanding dysregulation in grey matter disorders to brain architectures dole out next-generation AI.

Honors and awards

Sur has been elected to rank membership of the National Institute of Medicine USA, the Imperial Society of London, the Denizen Academy of Arts and Sciences, the Indian National Science Establishment and the World Academy tactic Sciences.

He has also antediluvian elected to the American Federation for the Advancement of Body of knowledge, the National Academy of Sciences, India, the Rodin Academy Sverige, and the Neurosciences Research Document. He has been awarded nobility Krieg Cortical Discoverer Prize (2016) and the Doctor of Body of knowledge honoris causa from Indian School of Technology, Kanpur (2017).

Dirt has received the Charles Judson Herrick Award from the Denizen Association of Anatomists (1983), blue blood the gentry A.P. Sloan Foundation Fellowship (1985), the McKnight Neuroscience Development Bestow (1988), the School of Branch Prize for Excellence in Calibrate Teaching (2000), the Distinguished Ultramarine Lectureship of the Australian Neuroscience Society (2000), the Sigma Xi Distinguished Lectureship (2001), and distinction Distinguished Alumnus Award of IIT Kanpur (2002), and named amidst the top 50 alumni catch the fancy of IIT Kanpur (2010).

He has been honoured at MIT shrivel the Hans-Lukas Teuber Scholar Honour in the Brain Sciences (1997), the Sherman Fairchild Chair (1998), and the Newton Chair (2008).

Major publications

Selected from over 280 publications.
  • Sur, M., P.E. Garraghty post A.W. Roe. Experimentally induced visible projections into auditory thalamus last cortex.

    Science 242: 1437–1441, 1988.

  • Hahm, J.-O., R.B. Langdon and Assortment. Sur. Disruption of retinogeniculate centripetal segregation by antagonists to NMDA receptors. Nature 351: 568–570, 1991.
  • Nelson, S., L. Toth, B. Sheth, and M. Sur. Orientation selectivity of cortical neurons persists through intracellular blockade of inhibition. Branch of knowledge 265: 774–777, 1994.
  • Somers, D.C., S.B.

    Nelson and M. Sur. Veto emergent model of orientation selectivity in cat visual cortical elementary cells. Journal of Neuroscience 15: 5448–5465, 1995.

  • Sharma, J., A. Angelucci and M. Sur. Induction unmoving visual orientation modules in ear cortex. Nature 404: 841–847, 2000.
  • Von Melchner, L., S.L.

    Pallas topmost M. Sur. Visual behaviour mediated by retinal projections directed connect the auditory pathway. Nature 404: 871–876, 2000.

  • Weng, J., J. McClelland, A. Pentland, O. Sporns, Unrestrained. Stockman, M. Sur and Tie. Thelen. Autonomous mental development because of robots and animals. Science 291: 599–600, 2001.
  • Dragoi, V., J.

    Sharma, E.K. Miller and M. Port. Dynamics of neuronal sensitivity overfull visual cortex and local thing discrimination. Nature Neuroscience 5: 883–891, 2002.

  • Newton, J.R., C. Ellsworth, Routine. Miyakawa, S. Tonegawa and Grouping. Sur. Acceleration of visually cued conditioned fear through the chance to speak pathway.

    Nature Neuroscience 7: 968–973, 2004.

  • Sur, M. and J. Rubenstein. Patterning and plasticity of character cerebral cortex. Science 310: 805–810, 2005.
  • Mariño J., J. Schummers, D.C. Lyon, L. Schwabe, O. Bayou, P. Wiesing, K. Obermayer subject M. Sur. Invariant computations delete local cortical networks with unprejudiced excitation and inhibition.

    Nature Neuroscience 8: 194–201, 2005.

  • Tropea, D., Blurred. Kreiman, A. Lyckman, S. Mukherjee, H. Yu, S. Horng become peaceful M. Sur. Gene expression shift variations and molecular pathways mediating activity-dependent plasticity in visual cortex. Separate Neuroscience 9: 660–668, 2006.
  • Schummers, J., H.

    Yu and M. Port. Tuned responses of astrocytes subject their influence on hemodynamic signals in the visual cortex. Branch of knowledge 320: 1638–1643, 2008.

  • Tropea, D., Heritage. Giacometti, N. R. Wilson, Apothegm. Beard, C. McCurry, D. Fu, R. Flannery, R. Jaenisch, charge M. Sur. Partial reversal accept Rett-Syndrome like symptoms in MeCP2 mutant mice.

    Proceedings of grandeur National Academy of Sciences 106: 2029–2034, 2009.

  • McCurry, C.L., J.D. Usher, D. Tropea, K.H. Wang, M.F. Bear and M. Sur. Failure of Arc renders the chart cortex impervious to the gear of sensory deprivation or be aware of. Nature Neuroscience 13: 450–457, 2010.
  • Wilson, N.R., C.A. Runyan, F.L. Wang, and M.

    Sur. Division stand for subtraction by distinct cortical inoculant networks in vivo. Nature 488: 343-348, 2012.

  • Chen, N., H. Sugihara, J. Sharma, G. Perea, Count. Petravicz, C. Le, and Class. Sur. Nucleus basalis enabled push specific plasticity in the chart cortex is mediated by astrocytes. Proceedings of the National Faculty of Sciences 109: E2832–E2841, 2012.
  • Chen, N., H.

    Sugihara and Assortment. Sur. An acetylcholine-activated microcircuit drives temporal dynamics of cortical mania. Nature Neuroscience 18: 892-902 [doi: 10.1038/nn.4002], 2015.

  • Goard, M.J., G.N. Pho, J. Woodson and M. Tyre. Distinct roles of visual, parietal, and frontal motor cortices comic story memory-guided sensorimotor decisions.

    eLife 5: e13764. [doi: 10.7554/eLife.13764], 2016.

  • El-Boustani, S., J.P.K. Ip, V. Breton-Provencher, Revolve. Okuno, H. Bito and Assortment. Sur. Locally coordinated synaptic rubberiness of visual cortex neurons gratify vivo. Science 360:1349-1354 [doi: 10.1126/science.aao0862], 2018.
  • Breton-Provencher, V., M.

    Sur. Refractory control of arousal by graceful locus coeruleus GABAergic circuit. Add Neuroscience 22: 218-228 [doi: 10.1038/s41593-018-0305-z], 2019.

  • Yildirim, M., H. Sugihara, P.T.C. So and M. Sur. Flexible imaging of visual cortical layers and subplate in awake mice with optimized three-photon microscopy. Rank Communications 10: 177 [doi: 10.1038/s41467-018-08179-6], 2019.
  • Tang X., R.

    Jaenisch, Collection. Sur. The role of GABAergic signalling in neurodevelopmental disorders. Makeup Reviews Neuroscience 22: 290-307 [1], 2021.

References